Pick, I'd be well satisfied with two cartridges for anything and everything from gophers and prairie dogs through the huge coastal bears of Alaska. If I were going after Cape buffalo or elephant, I'd add a third.
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<br>For varmints through deer, antelope, and caribou, I'd choose my .220 Howell with 75- or 80-grain bullets. Despite prevailing opinion about .224s on these smaller big game, this cartridge and others like it have proved in the field to be impressively deadly on this class of big game.
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<br>For the bigger American game, I'd love to be able to choose either my .340, .350, or .380 Howell -- but these require their own brass for best results, and I'm afraid their brass is soon to be unavailable. (Hope not!) As a second choice in this category, then, I'd go with the .338-.280 RCBS or the .358 Norma Magnum.
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<br>For the biggest nasties, I'd be confident and comfortable with the .458 Winchester Magnum or (better) with either my .416 Howell (100 ft/sec faster than the justly famous Rigby, from a 2-1/2-inch case) or .450 Howell (my .416 with a bigger mouth).