Lots of ways to define most for least thus impossible to answer. I would suggest the good old trusty 30-30
A capable rifle for even larger game animals
Range adequate for 90+ % of shots one is likely to encounter.
Reloading is helped by lower pressures, gives 80-85% of most large 30's using approx 50% of powder
Factory ammo is probably the cheapest centerfire rifle ammo around with possibles exception of 223
