Academic question regarding sectional density.

Given the same bullet construction and weight, would you rather have a smaller caliber (and higher SD) or larger caliber (and lower SD) on big game?

Here's my situation. I'm deciding on what rifle/cartridge to get my recoil sensitive wife for a caribou hunt. It would be a major plus if the same load was appropriate for moose however it needs to be soft shooting so she can comfortably practice a lot with it. I've boiled it down to one of the 6.5's (swede, cm, or rem), 7mm-08 or a plain jane 308. I'm looking at loads of 140 grains in the 6.5, 150 in the 7, 150 in the 308. I reload.

I've been reading a lot about the 6.5's lately and their great SD advantages but I'm trying to weigh that against the conventional wisdom towards a 30 caliber. If I am going to be loading any of these cartridges in the 140-150 grain area to about 2700 fps, am I correct to lean more towards the 6.5 for higher SD and likely deeper penetration?

Thanks