I grew up hunting in ND when walking draws etc. was the preferred method so deer were usually on the move by the time they were seen. I can think of at least half a dozen that were on the run when I killed them. I'm sure it didn't do any wonders for the meat and I'm glad I learned how to use glassing to locate deer rather than boot leather. I haven't taken a running shot at a deer in years aside from one that jumped up and took off after being down for 30 seconds or so.