Paul C,
You could do far worse than mounting up a Leupold VX3 2.5-8x on your .375. After trying several scopes, I ended up with one on my .375 Ruger Hawkeye, and have found it to be ideal. It has been used in Argentina for Water Buff, Africa for small and large plains game, and in Texas for Nilgai, all with excellent results on game ranging from 20 yards to well over 250 yards.
The versatility of the .375 can definitely use some equal versatility in optics, IMO.
