Would I rather have my 99 .308? Yup. Will I most likely kill one with the 22-250? Yup. Generally hit what I aim at. Just feels weird. From growing up in Pa, I guess. Apparently, you need a 30-06 to kill Pa. deer. The farmer whose land I hunt uses a 22-250 to kill them up to around 400 yards. 55gr. Soft point. He is out to eliminate vermin, not eat deer, and isn't too upset if he doesn't find it till the next day. Doesn't happen much. They usually go right down.