After having shot a bunch of different superb, best quality custom rifles for articles, I believe that a good deal of fine accuracy comes from the four B's.
Finest quality Barrels, Bedding, Brass and Bullets.
Beyond that, barrel fitting, a truly square chamber and trued action undoubtedly help a lot.
As far as cartridge configuration ... I'm an agnostic; maybe, but prolly not.
Blessings,
Steve