Yep, I'm carrying the 140 grain X-Treme Penetrators in my Glock 40 and my Glock 20 and the 200 grain .45 X-Treme Penetrators in my Para Ordnance Executive Carry (3.2" barrel).
Why do you need that much penetration? Aren't you concerned about passing through without much velocity loss? If you're in grizzly country, and all you have is a .40 or .45, I guess I could see it, but not in an ordinary self-defense carry situation.
