My only moose was a 42" Shiras. We'd been tracking him in new snow and I caught up with him bedded down, facing away from me. I shot him in the back of the neck from 80 yds. I was using a 30-06 with 180 gr bullets but I could have done the job with about anything larger than a 22 cal and with a good bullet. Even a 22 cal might have worked ok but I don't like to push it.