Those are really small markets.
But that's ok. You don't have to make money on every product, and producing small runs of rifles chambered for cool cartridges pays off in other ways that aren't always easy to quantify but it shows customers that the company "gets it". For example, I bought a CZ Bren 2s recently of which CZ only imported 300 or so to the US. The low import numbers of the excellent 2s, which led to higher prices on GB and similar, generated interest in the Bren 2 Ms which is available in much higher quantities at lower cost and most likely offers CZ higher margins.
Ruger is a company that "gets it". They're ok with spending R&D money on concepts in anticipation of possible changes in availability and demand and that's not something I read.
