There's no reason a .280 can't be loaded to the same pressures as the .270 in modern guns.
That was where I was leadin'........
If the particular rifle was offered chambered in .270Win, it certainly could handle a .280 Rem loaded like it should be loaded!
The .280 is an excellent round. It benefits from quality handloads just like a .270 or a .30-06 does.