I also shoot the Hornady 180 flat base
I've tried H4831, H1000, Re22, RE25, Ramshot Magnum and VVN165.
I keep going back to H4350.
In my rifle I get better accuracy and single digit extreme spread using H4350, Non of the other powders could beat that. They did give me an average of 75-125 fps more velocity which is insignificant in the field.

Big guns can be loaded down to little gun levels. Little guns are always little guns.