Magnumb, my experience is they will do exactly what you say, but as with any hard cast bullet, I expect the animal to run about 3 or 4 times as far as if they were hit with a rifle (say a .30-06, .270, .300, etc.). I have seen two large wild boars drag their front legs for a couple of hundred yards with 3 or 4 WFNs through their shoulders. And, having shot or witnessed the shooting of 30 or so animals with hard cast bullets through .44 Magnums, hot-loaded .45 colts and .454s, I would say somewhere between 100-200 yards is an average run if hit through the lungs or shoulders.

While I still like shooting and hunting with handguns, my experience is modern Rifles do more damage and put them down quicker.