Jason280: "I" wish life were that simple!
In my experience its not.
I am loading for a total of 8 (eight) Rifles in the calibers you specifically mention (NO etc's included) and I am using 7 (seven) different powders in those 8 (eight) Rifles!
My objective in handloading for these Varmint and Big Game Rifles is finding the top attainable accuracy in each with the bullet I want to shoot in that rig.
I am not sure what your "other" objective besides just simplifying your shopping - again I wish life were that simple.
I have been having a hard time replacing the powders I've used up of late with ANY size container of powder.
I say reconsider - and find THE powder that suits THE individual Rifles you are handloading for and then work on obtaining the powder (and other components) that suits that Rifle and your needs for that Rifle the best. Lay in a supply - if nothing else there would be peace of mind once that is accomplished.
I have countless friends that only buy bulk powders and they buy it in bulk for their individual Rifles.
Again, I indeed wish there were just "ONE" powder that would be "the best" in all my 243's, 25/06's, 270's and in my 280 Remington!
I don't think that is a reasonable goal though.
Best of luck to ya!
Hold into the wind
VarmintGuy