I see a lot of talk about RL-17, and my experience loading for the 375 Ruger was using RL-15. With 74 grains of RL-15 I was getting right at 2750, and a scary small groups.I also used a similar amount of powder for 260 grain Accubonds and Partitions, it shot all 3 veery well. But for some reason to me the 270 TSX seemed about like the perfect combination for that rifle. Only thing I ever killed with the 375 Ruger was a black bear and not a real big one.I used the factory 270 SP. The 375 Ruger sent that poor blackie to bear heaven with the quickness. Devastating killing ability!