JPK,
I don't really understand your point..I handload and have no trouble what so ever getting those velocities that I quoted.

I understand a wider cross section is a better stopper, but a 300 gr. bullet is a 300 gr. bullet and the .338 has the better sectional density thus better penetration than a .375 and that has to count too, but all that is anal tech, the facts are you can't tell the differnce betweent the two....

I would suggest that you have not used the .338 Win. on buffalo based on your post..I admit its not the ideal buffalo round, but that is not the issue here, the question was will it work and the answer is it will, and it works rather well IMO..Would I prefer a .375? probably but its not a big deal to me one way or the other..I would feel equally armed with a 338 Win., 9.3x62 or .375, albiet perhaps mentally the .375 would provide a modicum of comfort! smile. I would feel like I had a very definate edge over them all with a 416 Rem., Ruger or Rigby or a 404 Jefferys.