I have both of these fine calibers, and they both will do about the same things. Another good comparison is the 140 grain in the .270 and the 165 grain bullet in the .308. The .270 is very flat shooting, but so is the .308. I am partial to the .308 simply because I like 30 caliber bullets, and .308s are noted for their accuracy. The .270 with good bullets is a western mule deer hunter's best friend. I wouldn'd lose any sleep over choosing either one because they are both excellent choices.