the only real advantage if it exists is more area of expasion on the larger pill after penetration, and larger wound channel of the 308.<BR> now that being said if the advantage exists it would be on specific sized game at specific ranges, and that is actually the only true advantage besides possibly some downrange accuracy from less bullet drop, but actually a shooter should know where the pill is headed for whatever caliber pill combo he is using at whatever ranges he or she intends to shoot, that would actually be the real advantage knowing your weapons point of impact at the ranges you shoot.