A Ruger 375 Alaskan would be a good choice. I have a CZ550 which I like very much and which shoots 3 shot groups at 100 shooting Hornady 270gr with all shots touching. The only thing that would be the tie breaker for me as to which rifle to choose would be ammo
Is 375 Ruger available everywhere? As for the wood stock withstanding the Alaska wet, I would not worry about it. Take the rifle down in the evening, dry it out, and retorque your action screws to 55inch lbs or so and you should be good to go. The CZ550 is the working weapon of choice for lots and lots of PAes in Africa.