A 404 Jeff and a 416 are two different calibers. While there is no doubt the 458 is the better stopper, the 400gr/416 will handily out penetrate the 2100 fps 458. Again as a stopper, the 458 wins hands down.
As to the buffalo hunt, I'd beg to take issue with my dear friend ET. The 375 first shot was not optimally placed and the second one did it's job. Also keeping in mind it was a soft point whilst the 45-110s were using hard lead bullets. Incidentally mine did indeed poleaxe the buffalo, but it was a shoulder/spine shot which incidentally was stopped by the spine. Had that been a solid (comparable more or less to the hard lead 45-110s) those bullets would still be going. A 540gr (or 483 in my case) 458@ 1350 just cannot keep up in penetration to a 500 gr stell jacketed solid out of a 458 @2100 much less a 416@ 2400.
