I think it would work just fine.
Of course you won't get the expansion you would at 2700fps MV, but, as you pointed out, penetration should be right.
I don't have a lot of experience with that weight Interlock. Most of mine has been with the Hornady 165BTSP right at 2650fps out of my 20" Ruger 77.
It has done just fine on Caribou and whitetail deer.
Ed
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