Those 125 grainers will make it to 300 yds no problem and still have some steam left. I wouldn't shoot an Elk with one, but pasture poodles would be perfect fare. The main thrust of Safariman's advice is to learn to shoot the rifle without the accompanying full house recoil and concussion. Unless you're one of the few people on the planet that excessive recoil doesn�t affect, shooting too many 300 Weatherby-class rounds in a medium weight, un-braked rifle would cause a flinch in the best of us.