Big Game is a very good powder in the.375, particularly with 270-grain bullets. However, the Ramshot rifle powders don't tend to operate all that well until the load get up approaches 60,000 psi. Many "traditional" handloaders give up when starting loads don't group all that well, but if you keep adding powder the groups usually tighten up considerably.
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I've noticed this with TAC, and was about to give up on Big Game and the .260 Remington, but will keep working up with it.
