I ran a M70 Win Coyote lite in 22-250 (custom 22" medium contour barrel) for several years and loved it, but since I have switched over the rifle below.
More user friendly, side sling allows for more comfortable and universal carry, naturally the compact package is nice.
I run a 3.5-10x40 TMR Leupold and push HSM 50gr V Max out.
When the coyotes and bobcats get tougher at 300yrds plus I will go back to a bolt 22-250 or 243 but the 50gr V Max does the job well.
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Fast is Fine but Accuracy is Final.