Seems like there have been a lot of guys getting in to people and animals getting shot... can any of you guys share your input if you have seen the different calibers in similar situations and how much of a difference there is? I personally am a fan of larger calibers (45 acp) but often carry a 9. My roommate thinks the 9 will stop anything. Another thinks the .380 is plenty. Granted shot placement is key, but for you guys who have experience out there, how much of a difference is there in the larger calibers such as the .45 and 10mm over the .380 and 9mm?