Shot the buff with my handload, a 270 gr. Barnes TSX ahead of 81.0 gr. of Big Game powder, MV 2800 fps. Shot was 1/3 up the body, very tight behind the front leg. Bullet under the hide on the far side- perfect penetration on a 2000# animal.
Buff was found in the open grassland early in the morning, and distance was longish for a shot at water buffalo- 140 yards. Still lots of energy at that range with the 375 Ruger.
I know a professional hunter in Africa who says he would be mighty happy if every hunter that showed up (for buff or dang near anything):
