I use H380. It was the first powder I tried in my 22-250, I dumped 38 grs. into a few cases and seated a 55 gr. ballistic tip to kiss the lands then shot them, the first group went into one hole. I figured load workup was done and haven't seen a reason to change it since. It meters very well through the powder measure so I just set it and start throwing, makes it easy when loading 500 rounds for a prairie dog hunt. 38 grs. is a mild load (41 max from hodgdon) but still gives me over 3600 fps out of my rifle. I don't like throwing charges from a powder measure near max loads, but at 3 grs. under max I just throw them and go, it won't hurt anything if the measure throws a little heavy from time to time.
