Took to the middle of 4th page before someone mentioned BENCHMARK! As far as being fussy, I've never found the 22-250 to be fussy! Before the coming of VARGET, IMR 3031 was the powder that I thought would never be surpassed for usability across a wide range of chamberings.......222-375H&H. Then VARGET showed up and it works so well thru a measure and also that extreme range of capacity different cases. H380 got its name for 38.0 grains and 55 grain projectiles in the 22-250. 40 grains of WW 760 and tbe 52's works splendid also. The new releases, CFE and 8208 have given good test results also. But for now my go to powder for my own 22-250 (Ruger Target Gray) and a friends VSSF 22-250 is 33.5 grains of BENCHMARK. My rifle likes SIERRA 55BK and his shoots Nosler 55BT. .GHD