Hunting isn't self defense. Hunters can choose their shots.

Give me time and distance to put both hands on the gun, and lighting to see the target, and I'd feel completely confident taking a deer - or a Trayvon - with a .22 auto.

Put a Trayvon on top of me on a dark street with my glasses knocked off, and blood in my eyes, and only one hand free because the other one's trying to guard my face from being split open any further and hell yes I want a bigger gun.

There's a least bad compromise of concealability, followup split time, etc. to be found, and for me at least it isn't a large frame revolver. But it isn't a 380 either.