For deer no, but I would go along with the thought that a larger caliber may leave a better blood trail. No way of proving this and the .243 usually either drops them quickly or requires only a short distance to find.

For bigger hogs it seems on the light side for chest shots but no issues when head shots are taken.

I think the .260 would be a great compromise especially for a hand loader, it would overlap both the 6&7mm versions some with bullets in the 80-140 grn. range.

"When you disarm the people, you commence to offend them and show that you distrust them either through cowardice or lack of confidence, and both of these opinions generate hatred." Niccolo Machiavelli