My experience is from several years ago when my brother had a 243. He was using cup and core bullets on blacktail which generally run 110-125lbs.
I was with him when we saw a buck at about 150-200 yards. He shot it and it showed no effect and began to run. He shot 4 more times without any effect. Finally the deer just tipped over. When we skinned it, 4 of his 5 shots had gone through the lungs and there wasn't anything from the diaphragm forward that wouldn't pass through a window screen.
After hunting with the rifle for 5 seasons, he got tired of the meat damage and marginal performance and got a 308.
Granted this was not with today's premium bullets but my personal take is that if you want a coyote rifle that can take an occasional deer or are a very experienced hunter who can choose your shots, a 243 is OK but it would never be my first choice for a new hunter who may not wait for an ideal shot presentation or does not have the experience to recognize a hit and track down the animal.
