In fairness, the 110 VMax wouldn't be my choice for deep penetration.

Something along the lines of a 168-180 gr BTip, at 1700-1800 fps would probably dig deep, but not have as much tissue damage as a 110gr VMax.

I think there is still a lot to learn about using the 300 BO on deer, regarding bullet choice, velocity, terminal ballistics, and the faster twist rate.