Best of luck on your transplant surgery!
I'm only loading my .375 H&H Number one to 2620 fps with the 260 gr Nosler Accubond. Load from John Barsness, and doggone it's accurate. Have been using it for black bear, and it's working like a champ. Not much different from a warm .35 Whelen 250 gr load.
I kind of like those medium bore rifles, with bullets sort of loping along nice and easy like.
Regards, Guy