entirely depends upon the lady in question
if the wife carries, it's normally a jframe with laser sight
her bedside gun is a Glock 22, along with a spare mag, a surefire flashlight and a prepaid cell phone.
she won't train as often as I'd like her to, but damn she's a good shot, her hand eye coordination is exceptional.
a chick that's really into shooting, I'd opt for a semi auto
one that just wants to have a gun just in case, I'd probably opt for a revolver