I have a a handful of leupolds with LRD's. as mentioned they are meant to be used at max power. I have them on a 250AI, 6.5 CM, 7mm-08Ai, 300WSM and 338RCM I also have a 7 SAUM and a 308 with the Burris B-plex, pretty much a similar thing except the burris aiming point is better.
I will start by getting a decent zero at 200, but I wait for a nice still day and to the final zero with the 400yd dot at 400. The 300 yd dot and crosshairs might be off a touch but not much. For me its nice to know that I can pick up any of my standard rifles with dotz and know that crosshairs=200, 1st dot 300, 2nd dot=400 or close enough not to matter on anything coyote or larger. It keeps things simple.