In the pre Barnes TSX days of Alaska, it seems the famous bear guides I've read about liked the lighter weight bullets.

Pinell and Talifson were fans of the Remington Corelokt 270 gr in .375 H&H.

Runyon liked the 270 weight in the various .375's that he used. He moved on to various .40 wildcats using the old Barnes lead and copper "thin jacket" ( .32 ?).
I believe he also used a .350 Remington Mag as a loaner and used the 200 gr. Remington factory ammo.

Using the 270 Barnes TSX we have today would be win, win I think.