330's work fine if your using them on dry land and putting the trigger down. For water sets I'd stay away from them if possible. I prefer 280's.
After trapping huge numbers of otters with 220s and 330s, I respectfully submit the 330 is too big and otters get out of them every once in a while and the 220 is far, far more reliable.
A significant part of my otter experience is in tidal saltwater areas, but I have caught a bunch in a lot of different situations.