My experience with moose and Partitions and A-Frames mirrors what John just said. I generally shoot moose more than once. Often I'll 'try' another type bullet if I've put one into him lethally already. On two different occasions I've hit moose with Partition/A-Frame combos which were in other ways identical loads.

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The moose that caught this 250 A-Frame was fully ventilated by a Partition. (358 Norma; 200 yards approx.)

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Those two 140 Partitions were staggered with A-Frames of the same weight and loading in my 6.5x55. The moose which caught them was hit from a distance of somewhat less than 150 yards. All four bullets hit the chest and passed into the far leg. These two Partitions were tight against the far hide. The A-Frames were stopped by the muscles in the leg. (Since it was a shared hunt, I never collected those bullets.)

That's not to say that A-Frames are inferior in any way, but their superior weight retention doesn't necessarily translate into greater penetration.

Sometimes, the air you 'let in'matters less than the air you 'let out'.