Here is a few pics of a 300 gr. TSX (.416 Remington) recovered from my eland last year. The first shot was a bit far back in the lungs (my fault), and in an attempt to slow him down, I tried another shot at him after he turned to run. This one was found in his chest, after entering his right ham...for about 7' of penetration. For animals this size, I think the larger caliber, the better. Of course a .308 will work under ideal conditions and ideal shot placement, but how often do we get those?
True.
I have, like most folks who have gone to Africa, a copy of Kevin Robertson's 'The Perfect Shot'. Great illustrations of vital organs in animals with perfect broadside, or quartering, or frontal, shot placement.
Unfortunately, animals don't often present themselves in perfect shot positions, and this is where big calibers really shine.
My only Eland was a monster taken with a bow and a Muzzy 100 gr. broadhead, but if I were to take another one, it would almost certainly be with my .375 Ruger and either a 250 gr. Barnes TTSX or a 270 gr. TSX. Nothing against Accubonds, they just don't shoot as accurately out of my rifle as the Barnes bullets do.
