I got pressure signs at 78grs of RL-22 after switching from 165 gr SST. They advertise you could use the same load data, they were wrong. I got flat primers, and ejector marks as well.
I never did believe that statement even when Nosler said it about the eTips. The 180gr .308 eTip has so much more bearing surface than the Partition, BT, or AB, that if I were to seat it at the same OAL and use the same charge, I would get excessive pressure. When I posted my 180gr eTip load (52grs I4350 @ 3.255 OAL), some folks said that was too light of a load. I don't think they knew how long those bullets were. That load by the way is very accurate out of my Stevens 200 and at 100 yards is about a 4 inch drop from my 110gr Speer using 56grs of VARGET.
Hodgdon's load for 180gr Sierra SPBT using I4350 is 53 to 56.5C.
Since RL17 has been working so nicely, I might try that one next.