I've tried it with 150's in the .270, and it works great.
Accoridng to Hodgdon's data 4451 would be better--or at least faster--with 130's but I haven't tried it yet. Have tried 4451 in a few combinations where H4350 usually works well, such as 165-grain bullets in the .30-06, and it's been fine in all.
Have played around with 4166 in several cartridges and it works great as well, especially in the .308.