I'm just starting with 4166 in the 250 Savage. It may be a winner.
I shoot a 700 Classic and I duplicated Hodgdon's start and max loads with a 90 grain Sierra. The top load gave right at 3000 fps with no pressure signs to speak of. The Rem 9 1/2 primers looked unfired other than the firing pin dimple. Extraction was so easy it felt like I was working the bolt on an empty chamber.
