While not a .22-250, years ago I shot a medium sized doe with my .220 Swift and a factory loaded 46 gr. open point.. She ran maybe 75 yards and crashed.. But there wasn't a good blood trail.. It was open so I could keep track of her that way.. Still that is NOT a load I would want to take if I were looking to kill a nice buck.. Does were thick, and I waited for an easy shot.
