I have a Marlin 1894 Cowboy in 45 Colt, and a iron framed Uberti Henry in 44-40. Both are accurate and pleasant to shoot, the Henry will easily cut playing cards edgewise offhand at 25 yards. I have in fact killed two crows at 200 yards with the Henry.

On the other hand, if I were to hunt deer and had to choose between the two rifles, I would take the Marlin in 45 colt. Loaded with a 250 grain Keith style bullet and 8.5 grains of Unique, it is a really reliable killer, and will shoot through and through the shoulders of a deer at 100 yards. The other side of the coin is that I once shot a coyote on the shoulder with the 44-40 Henry, and it didn't go all the way through. I just think the 45 Colt is a much more effective cartridge.