I tend to look at things differently, if I buy or build a rifle it's to have the rifle in the caliber I want to work with or play with. Hunting deer is such a non-demanding activity, every rifle I have ever owned was fine and worked well for that, and there have been hundreds.
So I'd say to pick the caliber you find interesting that's available in the rifle you really want to own. There are a lot of rifles available in the 6.5 Creed now, with the right twist, that seem to perform well right out of the gate...so add that to the list of the other hundred calibers that will effectively handle a deer.
