I used 260 grain Nosler Partitions loaded to 2710 fps in my 375 H&H in Africa on Impala (whitetail) and Kudu (moose). I wouldn't hesitate to use it again; 200 yard shot on Impala and 270 yards on a trotting Kudu. This shoots with the trajectory of a 30-06 for longer ranges.

PA Bear Hunter, NRA Benefactor Member