I've never put that many miles on a pickup, but my Dad's 73 Chevy 4x4 was worn out at 53000 miles. The cam lobes were so worn it couldn't be properly timed, was on it's 4th clutch, and the 4wd lever was loose as can be. It was was 17 years old, had fed cows every day of the winter feeding season for that time, and had hauled fuel, a sprayer, and gone fencing and farming all those summers. He changed oil every 800 miles since it seldom saw more than 10 miles of highway at a time.
The guy who now leases that farm has a 96 F250 with the 460 motor. Was riding with him noticed it wasn't pulling too well, asked him how many miles. He said he wasn't sure cause there was so much dust behind the plastic in front of the odometer, but the first number was a 4! But along with the farming/feeding miles he puts a lot of highway miles on too.