I use them to pot the occasional backyard squirrel, no sweat. Accuracy in my bolt guns and target rifles, meh. But then again I'm spoiled as I mainly shoot premium target ammo in them.
As for using high speed hollow points for hunting, I haven't done that since circa 1982. An Eley Tenex in a squirrel's head means lights out, and a chest hit ditto. Rabbits and other edible small game, no difference in my experience- and I've been doing this for 50 years now.