I'm a big fan of a 255 grain LSWC @ 1000fps out of a 5 1/2'' Ruger single action in .45 Colt for whitetails and smaller.

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One of these days, I'd love to take an elk and a moose with a .45 Colt. I've got a batch of LBT 300 grain WFN hard cast slugs loaded to 1200fps sitting on a shelf just waiting for the opportunity.