Took mine with Nosler Partition. 300 Weatherby Magnum factory load. Actually a brown bear. 9'6". Quartering shot bullet went in front shoulder. Came out off rear hip. Maybe 4 full feet of body tissue. Unfortunately the slug broke no bones. Liver shot him terminal. When slug came out the far end, a about cantaloupe sized ball of his guts was hanging out the exit hole. Extreme superb bullet performance. Wouldn't hesitate a second to use it in a 375. Same goes for the A-Frame. Be safe, take pictures and update us. I am envious.